Cellular environment is important in controlling V-ATPase dissociation and its dependence on activity.

@article{Qi2007CellularEI,
  title={Cellular environment is important in controlling V-ATPase dissociation and its dependence on activity.},
  author={Jie Qi and Michael Forgac},
  journal={The Journal of biological chemistry},
  year={2007},
  volume={282 34},
  pages={24743-51}
}
One mechanism of regulating V-ATPase activity in vivo involves reversible dissociation into its component V(1) and V(0) domains, which in yeast occurs in response to glucose depletion. V-ATPase complexes containing the Vph1p isoform of subunit a (VCC) are targeted to the vacuole, and Stv1p-containing complexes (SCC) are targeted to the Golgi. Overexpression… CONTINUE READING