Cellular energy utilization and molecular origin of standard metabolic rate in mammals.
@article{Rolfe1997CellularEU, title={Cellular energy utilization and molecular origin of standard metabolic rate in mammals.}, author={D F Rolfe and Guy C. Brown}, journal={Physiological reviews}, year={1997}, volume={77 3}, pages={ 731-58 } }
The molecular origin of standard metabolic rate and thermogenesis in mammals is examined. It is pointed out that there are important differences and distinctions between the cellular reactions that 1) couple to oxygen consumption, 2) uncouple metabolism, 3) hydrolyze ATP, 4) control metabolic rate, 5) regulate metabolic rate, 6) produce heat, and 7) dissipate free energy. The quantitative contribution of different cellular reactions to these processes is assessed in mammals. We estimate that…
1,675 Citations
Energy metabolism, thyroid calorigenesis, and oxidative stress: functional and cytotoxic consequences
- Biology, ChemistryRedox report : communications in free radical research
- 2000
A sigmoidal relation is observed between the specific rate of mitochondrial oxidative phosphorylation and the concentration of cytosolic ADP in human skeletal Muscle in vivo, a kinetic response that agrees with data found in canine heart muscle in vivo and in the ex situ perfused mouse liver.
Modeling Biochemical Aspects of Energy Metabolism in Mammals
- Biology
- 2002
A framework representing the major biochemical pathways of nutrient metabolism is developed allowing quantification of the energy efficiency of different nutritional scenarios and it is hypothesized that energy derived from amino acid catabolism may affect the ultimate utilization of this energy.
Improved mitochondrial coupling as a response to high mass-specific metabolic rate in extremely small mammals
- BiologyJournal of Experimental Biology
- 2020
An extremely small mammal, Mus mattheyi, exhibits lower cellular oxygen consumption and higher mitochondrial efficiency than predicted from allometric trends, generating more cellular energy per oxygen molecule to ensure its homeostasis.
Allometry of mitochondrial efficiency is set by metabolic intensity
- BiologyProceedings of the Royal Society B
- 2019
It is shown that large mammals exhibit a faster dynamic increase in ATP/O than small species when mitochondria shift from basal to maximal activities and the invariant value of maximal coupling efficiency across mammal species could partly explain why scaling exponent values are very close to 1 at maximal metabolic rates.
Improved mitochondrial coupling as a response to high mass-specific metabolic rate in extremely small mammals.
- BiologyThe Journal of experimental biology
- 2020
The present study investigates the impact of body mass variation on cellular and mitochondrial functioning in small mammals, comparing the two extremely small African pygmy mice with the larger house mouse, finding M. mattheyi had generally the lowest cellular and mitochondria fluxes, depending on the tissue considered, as well as having higher efficient muscle mitochondria than the other two species.
Role of membranes in determining the molecular activity of the sodium pump
- Biology
- 2000
The aims of this study are to investigate the molecular activities of sodium pumps in endotherms and ectotherms, as well as to see if any similar changes occur for the sodium pump during mammalian development, and to determine if any factors are associated with sodium pump molecular activity, and membrane composition by a complete analysis of membrane composition.
Contribution of anaerobic energy expenditure to whole body thermogenesis
- BiologyNutrition & metabolism
- 2005
This manuscript incorporates contemporary bioenergetic interpretations of anaerobic and aerobic ATP turnover to promote the independence of these disparate types of metabolic energy transfer.
Matching cellular metabolic supply and demand in energy-stressed animals.
- BiologyComparative biochemistry and physiology. Part A, Molecular & integrative physiology
- 2009
On the role of the mitochondrial 2-oxoglutarate dehydrogenase complex in amino acid metabolism
- Biology, ChemistryAmino Acids
- 2012
It is shown that organisms possessing OGDHC respond to SP by significantly changing their amino acid pools, and strong perturbation in the relative abundance of amino acids due to the OGD HC inhibition was accompanied by decreased protein content.
Different Views on the Tissue Thermogenesis of Organisms
- Biology
- 2018
This review critically analyzes the problem of low efficiency of biological processes and examines alternative ways of tissue thermogenesis, including uncoupled respiration, which proceeds more intensively in tissues of endothermic animals than in ectothermic organisms.
References
SHOWING 1-10 OF 156 REFERENCES
Body mass dependence of H+ leak in mitochondria and its relevance to metabolic rate
- BiologyNature
- 1993
Proton leak decreases with increasing body mass in mammals, and it is suggested that differences in proton leak may partly explain the differences in standard metabolic rate between mammals of different mass.
A hierarchy of ATP-consuming processes in mammalian cells.
- BiologyThe Biochemical journal
- 1995
There was a clear hierarchy of the responses of different energy-consuming reactions to changes in energy supply: pathways of macromolecule biosynthesis were most sensitive to energy supply, followed by sodium cycling and then calcium cycling across the plasma membrane.
Respiration in Myocardium
- BiologyNature
- 1968
The relative contribution of non-phosphorylating and non-mitochondrial oxygen uptake to total respiration in vivo has been studied in the isolated perfused rat heart.
ATP and Brain Function
- Biology, ChemistryJournal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism
- 1989
The importance of A TP as the main source of chemical energy in living matter and its involve ment in cellular processes has long been recog nized. The primary mechanism whereby higher or ganisms,…
Quantification of the contribution of various steps to the control of mitochondrial respiration.
- BiologyThe Journal of biological chemistry
- 1982
Inference titration studies were carried out in order to quantify the amount of control (control strength) exerted by different steps in oxidative phosphorylation on the rate of mitochondrial oxygen uptake.
The contribution of the leak of protons across the mitochondrial inner membrane to standard metabolic rate.
- BiologyJournal of theoretical biology
- 1990
ConA induced changes in energy metabolism of rat thymocytes
- BiologyBioscience reports
- 1992
The pattern of energy metabolism in stimulated thymocytes is similar to that described for Ehrlich Ascites tumour cells and splenocytes, which may also be in an activated state, so the unexplained process(es) in unstimulated cells shut(s) off on stimulation.
Control of respiration and ATP synthesis in mammalian mitochondria and cells.
- BiologyThe Biochemical journal
- 1992
We have seen that there is no simple answer to the question 'what controls respiration?' The answer varies with (a) the size of the system examined (mitochondria, cell or organ), (b) the conditions…
Characterisation of the control of respiration in potato tuber mitochondria using the top-down approach of metabolic control analysis.
- BiologyEuropean journal of biochemistry
- 1992
Control over oxidative phosphorylation by purified potato mitochondria was determined using the top-down approach of metabolic control analysis, reflecting the way the system operates to keep the protonmotive force fairly constant.