Cellular energy utilization and molecular origin of standard metabolic rate in mammals.

  title={Cellular energy utilization and molecular origin of standard metabolic rate in mammals.},
  author={D F Rolfe and Guy C. Brown},
  journal={Physiological reviews},
  volume={77 3},
The molecular origin of standard metabolic rate and thermogenesis in mammals is examined. It is pointed out that there are important differences and distinctions between the cellular reactions that 1) couple to oxygen consumption, 2) uncouple metabolism, 3) hydrolyze ATP, 4) control metabolic rate, 5) regulate metabolic rate, 6) produce heat, and 7) dissipate free energy. The quantitative contribution of different cellular reactions to these processes is assessed in mammals. We estimate that… 

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