Cellular energy sensing and signaling by AMP-activated protein kinase

@article{Winder2007CellularES,
  title={Cellular energy sensing and signaling by AMP-activated protein kinase},
  author={William Winder and David M. P. Thomson},
  journal={Cell Biochemistry and Biophysics},
  year={2007},
  volume={47},
  pages={332-347}
}
AMP-activated protein kinase (AMPK) is an energy sensing/signaling protein that, when activated, increases ATP production by stimulating glucose uptake and fatty acid oxidation while at the same time inhibiting ATP=consuming processes such as protein synthesis. Chronic activation of AMPK inhibits expression of lipogenic enzymes in the liver and enhances expression of mitochondrial oxidative enzymes in skeletal muscle. Deficiency of muscle LKB1, the upstream kinase of AMPK, results in greater… CONTINUE READING

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