Cellular electrophysiological effects of flecainide on human atrial fibres.

@article{Grand1990CellularEE,
  title={Cellular electrophysiological effects of flecainide on human atrial fibres.},
  author={Bruno Le Grand and Jean-Yves le Heuzey and Patrick Perier and Pierre P{\'e}ronneau and T K Lavergne and St{\'e}phane Nicolas Hatem and Louis Guize},
  journal={Cardiovascular research},
  year={1990},
  volume={24 3},
  pages={232-8}
}
STUDY OBJECTIVE The aim of the study was to examine the electrophysiological characteristics of human atrial specimens collected during heart surgery and to investigate the effects of the class I antiarrhythmic agent flecainide on their electrical activity. DESIGN Atrial specimens were studied using standard microelectrode techniques, with and without superfused flecainide (5 x 10(-7) M) or the transient outward current inhibitor 4-aminopyridine (0.5 mM). EXPERIMENTAL MATERIAL Atrial… CONTINUE READING

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Twenty-five years in the making: flecainide is safe and effective for the management of atrial fibrillation

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Termination of atrial fibrillation by flecainide: mechanistic insights from spectral analysis.

Europace : European pacing, arrhythmias, and cardiac electrophysiology : journal of the working groups on cardiac pacing, arrhythmias, and cardiac cellular electrophysiology of the European Society of Cardiology • 2010

Suitability of Genetic Algorithm Generated Models to Simulate Atrial Fibrillation and K+Channel Blockades

2005 IEEE Engineering in Medicine and Biology 27th Annual Conference • 2005
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