Cellular effects of purvalanol A: a specific inhibitor of cyclin-dependent kinase activities.

@article{Villerbu2002CellularEO,
  title={Cellular effects of purvalanol A: a specific inhibitor of cyclin-dependent kinase activities.},
  author={Nathalie Villerbu and A M Gaben and G{\'e}rard Redeuilh and Jan Mester},
  journal={International journal of cancer},
  year={2002},
  volume={97 6},
  pages={761-9}
}
We have studied the effects of purvalanol A on the cell cycle progression, proliferation and viability. In synchronized cells, purvalanol A induced a reversible arrest the progression in G1 and G2 phase of the cell cycle, but did not prevent the completion of DNA synthesis in S-phase cells. The specificity of action of the drug was supported by the selective inhibition of the phosphorylation of cyclin-dependent kinase (cdk) substrates such as Rb and cyclin E. The cell contents of cyclins D1 and… CONTINUE READING

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