Cellular effects of hyperthermia: relevance to the minimum dose for thermal damage.

  • James R. Lepock
  • Published 2003 in
    International journal of hyperthermia : the…
The specific mechanism of cell killing by hyperthermia is unknown, but the high activation energy of cell killing and other responses to hyperthermia suggest that protein denaturation is the rate-limiting step. Protein denaturation can be directly monitored by differential scanning calorimetry and in general there is a good correlation between protein… CONTINUE READING