Cellular effects of CPT-11 on colon carcinoma cells: dependence on p53 and hMLH1 status.

@article{Magrini2002CellularEO,
  title={Cellular effects of CPT-11 on colon carcinoma cells: dependence on p53 and hMLH1 status.},
  author={Roberta Magrini and Mandar Ramesh Bhonde and M. T. Hanski and Michael Notter and Hans Scher{\"u}bl and Clement Richard Boland and Martin Zeitz and Christoph Hanski},
  journal={International journal of cancer},
  year={2002},
  volume={101 1},
  pages={23-31}
}
Irinotecan (CPT-11), a recently introduced component of a standard chemotherapy for colorectal cancer, induces in colon cancer cell lines in vitro cell cycle arrest and apoptosis. Since sporadic colon carcinomas exhibit in 50-60% mutations in the p53 gene and in 10-15% an MSI phenotype due in the great majority of the cases to hMLH1 inactivation, we investigated how these lesions influence the cellular effects of CPT-11 by using colorectal carcinoma cell line HCT116 (which has the genotype p53… CONTINUE READING

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