Cellular effector mechanisms against Plasmodium liver stages.

  title={Cellular effector mechanisms against Plasmodium liver stages.},
  author={Ute Frevert and Elizabeth H. Nardin},
  journal={Cellular microbiology},
  volume={10 10},
Advances in our understanding of the molecular and cell biology of the malaria parasite have led to new vaccine development efforts resulting in a pipeline of over 40 candidates undergoing clinical phase I-III trials. Vaccine-induced CD4+ and CD8+ T cells specific for pre-erythrocytic stage antigens have been found to express cytolytic and multi-cytokine effector functions that support a key role for these T cells within the hepatic environment. However, little is known of the cellular… CONTINUE READING

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