Cellular distribution of the endothelin system in the human brain

@article{Naidoo2004CellularDO,
  title={Cellular distribution of the endothelin system in the human brain},
  author={V. Naidoo and S. Naidoo and R. Mahabeer and D. Raidoo},
  journal={Journal of Chemical Neuroanatomy},
  year={2004},
  volume={27},
  pages={87-98}
}
The vasoconstrictor endothelin-1 (ET-1) may also act as a neuropeptide. ET-1 is formed by the catalytic action of endothelin-converting enzyme-1 (ECE-1) on big ET-1 and its cellular actions are mediated via ET(A) and ET(B) receptors. Although localisation of these components in rodent brain has been extensively investigated, no single study has mapped their distribution in human brain. Here we describe the localisation of ET-1 mRNA, ET-1, ECE-1, ET(A) and ET(B) receptors within 24 human brain… Expand
Immunolocalisation of endothelin-1 in human brain
TLDR
The localisation of ET-1 and its subsequent correlation withET-1 mRNA in most of the regions investigated suggest a more extensive distribution of the ET system in the human brain than was previously identified. Expand
Endothelin-1 as a neuropeptide: neurotransmitter or neurovascular effects?
TLDR
There is a suggestion the ET-1 is a neuropeptide, based mainly on its histological identification in both the central and peripheral nervous system in a number of species, including man, and a variety of effects caused following its administration into different regions of the brain and by application to peripheral nerves are supported. Expand
Expression of endothelins and their receptors in glioblastoma cell lines
TLDR
Although the majority of glioblastoma cell lines in culture express ET isoforms and ET receptors, it is concluded that ET-1 and the ETB receptors are likely to mediate the effects of the ET system in gliobeasts. Expand
Tanshinone IIA inhibits endothelin-1 production in TNF-α-induced brain microvascular endothelial cells through suppression of endothelin-converting enzyme-1 synthesis
TLDR
It is suggested that Tan IIA may inhibit ET-1 production in TNF-α-induced BMVEC through the suppression of ECE-1 synthesis. Expand
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Localization of the endothelin system in human diffuse astrocytomas
TLDR
The localization of the entire ET‐1 system (ET‐1 mRNA, ET‐ 1, ECE‐1, ETA and ETB receptors) in surgical samples of human diffuse astrocytomas WHO Grade II is investigated. Expand
Endothelin-1 is elevated in Alzheimer's disease and upregulated by amyloid-β.
TLDR
Findings provide evidence of overactivity of the endothelin system in AD, further supporting the suggestion thatendothelin receptor antagonists may be of value for the treatment of this disease. Expand
Brain cellular localization of endothelin receptors A and B in a rodent model of diffuse traumatic brain injury
TLDR
The observed receptor shifts in this work may underlie the ET-1-mediated pathotrajectory of TBI including hypoperfusion as well as previous findings in other pathological states that show an apparent shift in the localization of ETrA and B. Expand
Differential circadian expression of endothelin-1 mRNA in the rat suprachiasmatic nucleus and peripheral tissues
TLDR
The diversity of rhythmic expressions among the SCN, whole brain, lungs and heart suggests that ET-1 has different functions in these tissues, as well as in peripheral tissues including the brain, heart, and lungs. Expand
Regulation of the norepinephrine transporter by endothelins: a potential therapeutic target.
TLDR
Current literature supports a key role for the interaction between ETs and NE in maintaining neurotransmission homeostasis and further suggests that this interaction may represent a potential therapeutic target for various diseases, particularly hypertension. Expand
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The localisation of ET-1 and its subsequent correlation withET-1 mRNA in most of the regions investigated suggest a more extensive distribution of the ET system in the human brain than was previously identified. Expand
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TLDR
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