Cellular distribution of phosphorothioate oligonucleotide following intravenous administration in mice.

@article{Zhao1998CellularDO,
  title={Cellular distribution of phosphorothioate oligonucleotide following intravenous administration in mice.},
  author={Qiuyan Zhao and Rulong Zhou and J. Temsamani and Z Zhang and A M Roskey and Sudhir Agrawal},
  journal={Antisense & nucleic acid drug development},
  year={1998},
  volume={8 6},
  pages={451-8}
}
Oligonucleotides are promising therapeutic agents for the prevention or treatment of a variety of diseases. The therapeutic potential of oligonucleotide therapy depends greatly on the bioavailability of oligonucleotides to their target cells and organs. We previously reported the pharmacokinetics and distribution of phosphorothioate oligonucleotide in mice using [35S]-labeled oligonucleotide ([35S]-oligo). To extend this study, we administered 30 mg/kg of fluorescent-labeled oligonucleotide… CONTINUE READING