Cellular distribution of glucose and monocarboxylate transporters in human brain white matter and multiple sclerosis lesions.

@article{Nijland2014CellularDO,
  title={Cellular distribution of glucose and monocarboxylate transporters in human brain white matter and multiple sclerosis lesions.},
  author={Philip G. Nijland and Iliana Michailidou and Maarten E. Witte and Mark Ronald Mizee and Susanne M. A. van der Pol and Bert van het Hof and Arie Reijerkerk and Luc Pellerin and Paul D. L. P. M. van der Valk and Helga Eveline de Vries and Jack van Horssen},
  journal={Glia},
  year={2014},
  volume={62 7},
  pages={1125-41}
}
To ensure efficient energy supply to the high demanding brain, nutrients are transported into brain cells via specific glucose (GLUT) and monocarboxylate transporters (MCT). Mitochondrial dysfunction and altered glucose metabolism are thought to play an important role in the progression of neurodegenerative diseases, including multiple sclerosis (MS). Here, we investigated the cellular localization of key GLUT and MCT proteins in human brain tissue of non-neurological controls and MS patients… CONTINUE READING
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