Cellular distribution of COT1 kinase in Neurospora crassa.

  title={Cellular distribution of COT1 kinase in Neurospora crassa.},
  author={Rena Gorovits and Klaas A. Sjollema and Johannes H. Sietsma and Oded Yarden},
  journal={Fungal genetics and biology : FG & B},
  volume={30 1},
The Neurospora crassa cot-1 gene encodes a Ser/Thr protein kinase, which is involved in hyphal elongation. Many vacuoles, abnormally shaped mitochondria, and nuclei, along with differences in the structure of the cell wall and hyphal septa, were observed in hyphae of the cot-1 mutant shortly after a shift to the restrictive temperature. Immunolocalization experiments indicated that COT1 was associated with the cytoplasmic membrane; COT1 was also detected in the cytoplasm. The membrane… CONTINUE READING

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