Cellular distribution, post-translational modification, and tumorigenic potential of human group III secreted phospholipase A(2).

@article{Murakami2005CellularDP,
  title={Cellular distribution, post-translational modification, and tumorigenic potential of human group III secreted phospholipase A(2).},
  author={Makoto Murakami and Seiko Masuda and Satoko Shimbara and Yukio Ishikawa and Toshiharu Ishii and Ichiro Kudo},
  journal={The Journal of biological chemistry},
  year={2005},
  volume={280 26},
  pages={24987-98}
}
Human group III secreted phospholipase A(2) (sPLA(2)-III) consists of a central group III sPLA(2) domain flanked by unique N- and C-terminal domains. We found that the sPLA(2) domain alone was sufficient for its catalytic activity and for its prostaglandin E(2) (PGE(2))-generating functions in various cell types. In several if not all cell types, the N- and C-terminal domains of sPLA(2)-III were proteolytically removed, leading to the production of the form containing only the sPLA(2) domain… CONTINUE READING