Cellular depolarization and cyclic nucleotide content in central nervous system.

@article{Ferrendelli1976CellularDA,
  title={Cellular depolarization and cyclic nucleotide content in central nervous system.},
  author={James Anthony Ferrendelli},
  journal={Advances in biochemical psychopharmacology},
  year={1976},
  volume={15},
  pages={
          303-13
        }
}
There is ample evidence indicating that cAMP and cGMP content in mamalian brain is markedly influenced by cellular depolarization. The relationships between the two cyclic nucleotides and the complex process of cellular depolarization, which in turn leads to extensive functional and metabolic consequences are incompletely understood, however. Much data, which are reviewed in the present chapter, suggest that cellular depolarization leads to elevation of cAMP and cGMP levels by two different and… CONTINUE READING