Cellular cyclic nucleotides and enzyme secretion in the pancreatic acinar cell.

@article{Haymovits1976CellularCN,
  title={Cellular cyclic nucleotides and enzyme secretion in the pancreatic acinar cell.},
  author={Asher Haymovits and George A Scheele},
  journal={Proceedings of the National Academy of Sciences of the United States of America},
  year={1976},
  volume={73 1},
  pages={156-60}
}
Cellular levels of cAMP and cGMP were measured in guinea pig pancreatic lobules incubated in vitro, during basal or stimulated secretion. Stimulation with optimal concentrations of carbamylcholine (carbachol) (10(-5) M), pancreozymin (0.1 unit/ml), and caerulein (10(-9) M) resulted within seconds in a sharp rise in cGMP levels, from five to more than 20 times that of basal levels. cAMP levels did not change significantly. cGMP increases were maximal at 2 min then subsided by 4-7 min to a… CONTINUE READING