Cellular consequences of thrombin-receptor activation.

  title={Cellular consequences of thrombin-receptor activation.},
  author={Roger J. A. Grand and Andrew S. Turnell and Peter W. Grabham},
  journal={The Biochemical journal},
  volume={313 ( Pt 2)},
To say that thrombin is a multi-functional protein is rather to understate the case. It is the key enzyme involved in haemostasis, playing important roles at all levels of complexity. First, in the coagulation cascade, thrombin converts fibrinogen into fibrin, which is readily cross-linked to form a clot (reviewed in [1,2]) ; secondly, thrombin activates blood platelets, causing aggregation and secretion [3,4] ; and thirdly, thrombin can elicit mitogenic responses from vascular smooth-muscle… CONTINUE READING
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Thrombin (Berliner, L

  • R. Bar-Shavit
  • J., ed.),
  • 1992

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