Cellular cofactors affecting hepatitis C virus infection and replication.

@article{Randall2007CellularCA,
  title={Cellular cofactors affecting hepatitis C virus infection and replication.},
  author={Glenn Randall and Maryline Panis and Jacob D. Cooper and Timothy L. Tellinghuisen and Karen E Sukhodolets and S{\'e}bastien Pfeffer and Markus Landthaler and Pablo Landgraf and Sherry Kan and Brett Lindenbach and Minchen Chien and David B. Weir and James J. Russo and Jingyue Ju and Michael J. Brownstein and Robert Sheridan and Chris Sander and Mihaela Zavolan and Thomas Tuschl and Charles M. Rice},
  journal={Proceedings of the National Academy of Sciences of the United States of America},
  year={2007},
  volume={104 31},
  pages={
          12884-9
        }
}
Recently identified hepatitis C virus (HCV) isolates that are infectious in cell culture provide a genetic system to evaluate the significance of virus-host interactions for HCV replication. We have completed a systematic RNAi screen wherein siRNAs were designed that target 62 host genes encoding proteins that physically interact with HCV RNA or proteins or belong to cellular pathways thought to modulate HCV infection. This includes 10 host proteins that we identify in this study to bind HCV… CONTINUE READING

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