Cellular characterisation of the GCKR P446L variant associated with type 2 diabetes risk

  title={Cellular characterisation of the GCKR P446L variant associated with type 2 diabetes risk},
  author={Matthew G. Rees and S. M. Wincovitch and Julia Schultz and Rica Waterstradt and Nicola L. Beer and Simone Baltrusch and Francis S. Collins and Anna L Gloyn},
Translation of genetic association signals into molecular mechanisms for diabetes has been slow. The glucokinase regulatory protein (GKRP; gene symbol GCKR) P446L variant, associated with inverse modulation of glucose- and lipid-related traits, has been shown to alter the kinetics of glucokinase (GCK) inhibition. As GCK inhibition is associated with nuclear sequestration, we aimed to determine whether this variant also alters the direct interaction between GKRP and GCK and their intracellular… CONTINUE READING


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