Cellular caspase-8-like inhibitory protein (cFLIP) prevents inhibition of muscle cell differentiation induced by cancer cells.

@article{Jiang2006CellularCI,
  title={Cellular caspase-8-like inhibitory protein (cFLIP) prevents inhibition of muscle cell differentiation induced by cancer cells.},
  author={Zhilong Jiang and Paula R. Clemens},
  journal={FASEB journal : official publication of the Federation of American Societies for Experimental Biology},
  year={2006},
  volume={20 14},
  pages={2570-2}
}
Cachexia is a frequent complication of cancer or other chronic diseases. To investigate the pathophysiology of cancer cachexia and pursue treatment options, we developed an in vitro assay of the effects of cancer cell-produced cytokines on primary muscle cells derived from murine skeletal muscle. These studies led to the novel observation that factors secreted by cell lines from prostate cancer and melanoma significantly inhibit differentiation of primary mouse muscle cells. The expression of… CONTINUE READING

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