Cellular biosensing using optical spectroscopy

  title={Cellular biosensing using optical spectroscopy},
  author={Adam Wax and Han Sang Park and Will J Eldridge},
Techniques such as optical nanoscopy1 and spectroscopy2 have expanded our capability to probe biological cells at the nanoscale. These techniques provide the opportunity to learn about disease mechanisms at the cellular level, and therefore to improve disease detection and diagnosis. Now we have developed approaches for cellular biosensing that use optical information at the nanoscale combined with spectroscopy to discriminate disease. Phase imaging has long been a mainstay of cell biology… CONTINUE READING

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Publications referenced by this paper.

Automated detection of P . falciparum using quantitative phase imaging of unstained cells

M. Rinehart, K. A. Walzer, J. T. A. Chi, andA. Wax
  • PLoS ONE , under review
  • 2016


A. Chmyrov, J. Keller, T. Grotjohann, M. Ratz
  • d’Este, S. Jakobs, C. Eggeling, and S. W. Hell, Nanoscopy with more than 100,000 doughnuts, Nat. Methods 10, pp. 737–740,
  • 2013

Optical methodology for detecting histologically unapparent nanoscale consequences of genetic alterations in biological cells

P. Pradhan, Y. Liu, +6 authors A. Taflove
  • Proc . Nat ’ l Acad . Sci . USA Quantitative Phase Imaging of Cells and Tissues
  • 2011

Quan - titative microscopy and nanoscopy of sickle red blood cells performed by wide field digital interferometry

L. L. Satterwhite, M. J. Telen, G. A. Truskey, A. Wax
  • J . Biomed . Opt .
  • 2011