Cellular biology of prion diseases.

  title={Cellular biology of prion diseases.},
  author={David A Harris},
  journal={Clinical microbiology reviews},
  volume={12 3},
Prion diseases are fatal neurodegenerative disorders of humans and animals that are important because of their impact on public health and because they exemplify a novel mechanism of infectivity and biological information transfer. These diseases are caused by conformational conversion of a normal host glycoprotein (PrPC) into an infectious isoform (PrPSc) that is devoid of nucleic acid. This review focuses on the current understanding of prion diseases at the cell biological level. The… CONTINUE READING


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