Cellular bioenergetics is regulated by PARP1 under resting conditions and during oxidative stress.

@article{Mdis2012CellularBI,
  title={Cellular bioenergetics is regulated by PARP1 under resting conditions and during oxidative stress.},
  author={Katalin M{\'o}dis and Domokos Gerő and Katalin Erdėlyi and Petra Szoleczky and Douglas S. Dewitt and Csaba Szab{\'o}},
  journal={Biochemical pharmacology},
  year={2012},
  volume={83 5},
  pages={633-43}
}
PURPOSE The goal of the current studies was to elucidate the role of the principal poly(ADP-ribose)polymerase isoform, PARP1 in the regulation of cellular energetics in endothelial cells under resting conditions and during oxidative stress. METHODS We utilized bEnd.3 endothelial cells and A549 human transformed epithelial cells. PARP1 was inhibited either by pharmacological inhibitors or by siRNA silencing. The Seahorse XF24 Extracellular Flux Analyzer was used to measure indices of… CONTINUE READING

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