Cellular bioenergetics changes in magnocellular neurons may affect copeptin expression in the late phase of sepsis.

@article{OliveiraPelegrin2014CellularBC,
  title={Cellular bioenergetics changes in magnocellular neurons may affect copeptin expression in the late phase of sepsis.},
  author={Gabriela Ravanelli de Oliveira-Pelegrin and Paulo Jos{\'e} Basso and Maria Jos{\'e} Alves da Rocha},
  journal={Journal of neuroimmunology},
  year={2014},
  volume={267 1-2},
  pages={28-34}
}
We investigated whether inflammatory mediators during cecal ligation and puncture (CLP)-induced sepsis may diminish copeptin expression in magnocellular neurons, thus affecting arginine-vasopressin (AVP) synthesis. The transcript abundance of IL-1β, IL-1R1, iNOS and HIF-1α was continuously elevated. IL-1β, iNOS and cytochrome c protein levels progressively increased until 24h. Immunostaining for these proteins was higher at 6 and 24h, as also seen in the annexin-V assay, while copeptin was… CONTINUE READING

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