Cellular binding partners of the human papillomavirus E6 protein

  title={Cellular binding partners of the human papillomavirus E6 protein},
  author={Sandy S. Tungteakkhun and Penelope Jayne Duerksen-Hughes},
  journal={Archives of Virology},
  pages={397 - 408}
The high-risk strains of human papillomavirus (HR-HPV) are known to be causative agents of cervical cancer and have recently also been implicated in cancers of the oropharynx. E6 is a potent oncogene of HR-HPVs, and its role in the progression to malignancy has been and continues to be explored. E6 is known to interact with and subsequently inactivate numerous cellular proteins pivotal in the mediation of apoptosis, transcription of tumor suppressor genes, maintenance of epithelial organization… CONTINUE READING


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