Cellular basis of working memory

@article{GoldmanRakic1995CellularBO,
  title={Cellular basis of working memory},
  author={Patricia S. Goldman-Rakic},
  journal={Neuron},
  year={1995},
  volume={14},
  pages={477-485}
}
In the presence of normal sensory and motor capacity, intelligent behavior is widely acknowledged to develop from the interaction of shortand long-term memory. While the behavioral, cellular, and molecular underpinnings of the long-term memory process have long been associated with the hippocampal formation, and this structure has become a major model system for the study of memory (Bliss and Lomo, 1973; McNaughton and Nadel, 1990; Squire and Zola-Morgan, 1991), the neural substrates of… Expand

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References

SHOWING 1-10 OF 103 REFERENCES
Neocortical memory circuits.
TLDR
Recent studies on the physiological properties of prefrontal neurons engaged in oculomotor memory tasks are reviewed and an under- standing of the prefrontal contribution to memory should allow more precise comparisons with that of the hippocampus and other brain regions. Expand
A memory system in the monkey.
  • M. Mishkin
  • Medicine, Biology
  • Philosophical transactions of the Royal Society of London. Series B, Biological sciences
  • 1982
A neural model is presented, based largely on evidence from studies in monkeys, postulating that coded representation of stimuli are stored in the higher-order sensory (i.e. association) areas of theExpand
The medial temporal lobe memory system
TLDR
The medial temporal lobe memory system is needed to bind together the distributed storage sites in neocortex that represent a whole memory, but the role of this system is only temporary, as time passes after learning, memory stored in neoc cortex gradually becomes independent of medialporal lobe structures. Expand
Parallel neuronal mechanisms for short-term memory.
TLDR
Recordings were made from neurons in the inferior temporal cortex of monkeys while the monkeys held a sample picture "in mind" and signaled when it was repeated in a sequence of pictures, ignoring other stimulus repetitions. Expand
Spatial working memory in humans as revealed by PET
TLDR
P positron emission tomography studies of regional cerebral blood flow in normal humans that reveal activation in right-hemisphere prefrontal, occipital, parietal and premotor cortices accompanying spatial working memory processes begin to uncover the circuitry of a working memory system in humans. Expand
Neuronal correlate of pictorial short-term memory in the primate temporal cortexYasushi Miyashita
TLDR
A group of shape-selective neurons in an anterior ventral part of the temporal cortex of monkeys that exhibited sustained activity during the delay period of a visual short-term memory task are reported. Expand
GABAergic Processes in the Central Visual System
There is now persuasive evidence that GABA is a primary inhibitory transmitter in the visual cortex and we have a reasonable knowledge of the morphological characteristics of the GABAergic cellsExpand
Circuitry, architecture, and functional dynamics of visual cortex.
  • C. Gilbert
  • Computer Science, Medicine
  • Cerebral cortex
  • 1993
TLDR
It has become increasingly possible to relate the responsive specificity of cortical cells, and the circuitry underlying this specificity, to the perceptual capabilities of the visual system by performing analogous experiments on single cells and in human psychophysics. Expand
Coactivation of prefrontal cortex and inferior parietal cortex in working memory tasks revealed by 2DG functional mapping in the rhesus monkey
TLDR
These are the first results showing concurrent metabolic activation of the prefrontal and parietal cortex in monkeys performing working memory tasks and they support the suggestion that these cortical regions represent two important nodes in a neural network mediating spatial working memory in the monkey. Expand
Mnemonic coding of visual space in the monkey's dorsolateral prefrontal cortex.
TLDR
An oculomotor delayed-response task was used to examine the spatial memory functions of neurons in primate prefrontal cortex and found that inhibitory responses were usually strongest for, or centered about, cue directions roughly opposite those optimal for excitatory responses. Expand
...
1
2
3
4
5
...