Cellular basis of negative inotropic effect of 2,3-butanedione monoxime in human myocardium.

@article{Perreault1992CellularBO,
  title={Cellular basis of negative inotropic effect of 2,3-butanedione monoxime in human myocardium.},
  author={Cynthia L. Perreault and Louis A. Mulieri and Norman R. Alpert and Bernard J. Ransil and P D Allen and James Plunkett Morgan},
  journal={The American journal of physiology},
  year={1992},
  volume={263 2 Pt 2},
  pages={H503-10}
}
2,3-Butanedione monoxime (BDM) exerts a marked negative inotropic effect and has been shown to have protective actions on human myocardial force production that may be of clinical use. To determine the underlying mechanisms, we studied the effects of BDM on chemically skinned and aequorin-loaded myopathic human myocardium from transplant recipients. Eighteen muscles were chemically skinned with saponin (250 micrograms/ml) and then subjected to activation-relaxation cycles, with and without 5 mM… CONTINUE READING