Cellular basis of insulin insensitivity in large rat adipocytes.

  title={Cellular basis of insulin insensitivity in large rat adipocytes.},
  author={M. Czech},
  journal={The Journal of clinical investigation},
  volume={57 6},
  • M. Czech
  • Published 1976 in The Journal of clinical investigation
The marked stimulatory effect of insulin on the conversion of 20 mM D-[6-14C]glucose to CO2, glyceride-glycerol, and fatty acid observed in small rat adipocytes was greatly diminished in large cells from older rats. Similarly, total glucose utilization as estimated by summing the total metabolites accumulated intracellularly plus the release of labeled CO2 and lactate was substantially lower in large cells in the presence of insulin and 5 mM labeled glucose. However, under conditions of 0.2 mM… CONTINUE READING


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