Cellular basis of immunologic interactions in adoptive T cell therapy of established metastases from a syngeneic murine sarcoma.

@article{Ward1988CellularBO,
  title={Cellular basis of immunologic interactions in adoptive T cell therapy of established metastases from a syngeneic murine sarcoma.},
  author={Barbara A Ward and Suyu Shu and T Leng Chou and Donna M Perry-Lalley and Alfred E. Chang},
  journal={Journal of immunology},
  year={1988},
  volume={141 3},
  pages={1047-53}
}
The adoptive transfer of specifically sensitized T lymphocytes can effectively mediate the regression of established local and metastatic tumors. Previous experiments using the weakly immunogenic MCA 105 sarcoma indicated that cellular interactions between transferred L3T4+ helper and Lyt-2+ cytotoxic immune T cells were necessary for mediating tumor regression. In this study, the kinetics of T-T cell interactions were analyzed by in vivo depletion of T cell subsets with mAb. The anti-tumor… CONTINUE READING

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