Cellular basis for the Brugada syndrome and other mechanisms of arrhythmogenesis associated with ST-segment elevation.

@article{Yan1999CellularBF,
  title={Cellular basis for the Brugada syndrome and other mechanisms of arrhythmogenesis associated with ST-segment elevation.},
  author={Gan-Xin Yan and Charles Antzelevitch},
  journal={Circulation},
  year={1999},
  volume={100 15},
  pages={
          1660-6
        }
}
BACKGROUND The Brugada syndrome is characterized by marked ST-segment elevation in the right precordial ECG leads and is associated with a high incidence of sudden and unexpected arrhythmic death. Our study examines the cellular basis for this syndrome. METHODS AND RESULTS Using arterially perfused wedges of canine right ventricle (RV), we simultaneously recorded transmembrane action potentials from 2 epicardial and 1 endocardial sites, together with unipolar electrograms and a transmural ECG… 

Figures from this paper

Cellular and ionic mechanisms responsible for the Brugada syndrome.

The Brugada syndrome is characterized by ST-segment elevation in the right precordial leads, V1-V3, normal QT intervals, RBBB pattern, and sudden cardiac death, particularly in men of Asian origin.

Mechanism of ST Elevation and Ventricular Arrhythmias in an Experimental Brugada Syndrome Model

Electrical heterogeneity in the recovery phase was induced in this experimental Brugada syndrome model, which can be a substrate for the development of phase 2 reentry and the subsequent reentry around an arc of the functional block, resulting in sustained VT.

Site‐Specific Arrhythmogenesis in Brugada Syndrome?

  • B. Belhassen
  • Medicine, Biology
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  • 2003
The electrophysiologic mode of induction of ventricular arrhythmias, especially with regard to the ventricular stimulation site, was studied in 45 patients with Brugada syndrome, and ventricular fibrillation (VF) was induced in 17 of their 45 patients.

The electrophysiologic mechanism of ST-segment elevation in Brugada syndrome.

Acquired forms of the Brugada syndrome.

  • W. Shimizu
  • Biology, Medicine
    Journal of electrocardiology
  • 2005
Any intervention that increases outward currents or decreases inward currents at the end of phase 1 of the AP can accentuate or unmask ST-segment elevation, similar to that found in the Brugada syndrome, thus producing acquired forms of the Bragada syndrome.

Delay in Right Ventricular Activation Contributes to Brugada Syndrome

Both proposed mechanisms of Brugada syndrome may be operative, as results indicate that both mechanisms must cause disparate contractile changes: delay in RV contraction and reduction of contractile force, respectively.
...

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