Cellular basis for reversal of hyperkalemic electrocardiographic changes by sodium.

@article{Ballantyne1975CellularBF,
  title={Cellular basis for reversal of hyperkalemic electrocardiographic changes by sodium.},
  author={Fiona C. Ballantyne and L. Douglas Davis and Edwin W. Reynolds},
  journal={The American journal of physiology},
  year={1975},
  volume={229 4},
  pages={
          935-40
        }
}
We examined the hypothesis that reversal of hyponatremic hyperkalemic electrocardiographic changes through the infusion of saline solutions was due to the action of sodium ion in increasing the action potential rising velocity which is depressed when the cell is exposed to increasing concentrations of potassium. Using standard microelectrode techniques, the rising velocity of canine ventricular cells was shown to increase by 21%, whereas conduction time between two microelectrodes decreased 17… CONTINUE READING
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