Cellular basis for long QT, transmural dispersion of repolarization, and torsade de pointes in the long QT syndrome.

@article{Shimizu1999CellularBF,
  title={Cellular basis for long QT, transmural dispersion of repolarization, and torsade de pointes in the long QT syndrome.},
  author={Wataru Shimizu and Charles Antzelevitch},
  journal={Journal of electrocardiology},
  year={1999},
  volume={32 Suppl},
  pages={177-84}
}
Genetic studies have identified four forms of congenital long QT syndrome (LQTS) caused by mutations in ion channel genes located on chromosomes 3 (LQT3), 7 (LQT2), 11 (LQT1), and 21 (LQT5). Preliminary clinical studies have reported different phenotypic electrocardiographic patterns and different sensitivity to pacing or pharmacological therapy for each genotype. A transmural electrocardiogram and transmembrane action potentials from epicardial, M, and endocardial cells were simultaneously… CONTINUE READING
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