Cellular bases for human atrial fibrillation

  title={Cellular bases for human atrial fibrillation},
  author={Antony J. Workman and Kathleen A. Kane and Andrew C. Rankin},
  booktitle={Heart rhythm},
Atrial fibrillation (AF) causes substantial morbidity and mortality. It may be triggered and sustained by either reentrant or nonreentrant electrical activity. Human atrial cellular refractory period is shortened in chronic AF, likely aiding reentry. The ionic and molecular mechanisms are not fully understood and may include increased inward rectifier K(+) current and altered Ca(2+) handling. Heart failure, a major cause of AF, may involve arrhythmogenic atrial electrical remodeling, but the… CONTINUE READING

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