Cellular aspects of atopic dermatitis.


Atopic dermatitis (AD) is a highly pruritic, chronic, and relapsing inflammatory skin disease. Recent interest in AD has been sparked by reports of its increasing prevalence and its contribution to increasing health care costs. A precise understanding of immunologic mechanisms is crucial for the development of effective treatment strategies for AD. Various studies reveal that AD has a multifactorial cause with the activation of complex immunologic and inflammatory pathways. This review will discuss cellular-mediated immunological pathomechanisms of AD. Emphasis will be given to the role played by T cells, antigen-presenting cells, eosinophils, and keratinocytes. We also examine the immunological effect of superantigens on various inflammatory cells including T regulatory cells.


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@article{Ou2007CellularAO, title={Cellular aspects of atopic dermatitis.}, author={L S Ou and Jing-Long Huang}, journal={Clinical reviews in allergy & immunology}, year={2007}, volume={33 3}, pages={191-8} }