Cellular arrhythmogenic effects of congenital and acquired long-QT syndrome in the heterogeneous myocardium.

@article{Viswanathan2000CellularAE,
  title={Cellular arrhythmogenic effects of congenital and acquired long-QT syndrome in the heterogeneous myocardium.},
  author={Prakash C. Viswanathan and Yoram Rudy},
  journal={Circulation},
  year={2000},
  volume={101 10},
  pages={1192-8}
}
BACKGROUND Certain alterations by mutations or drugs of the potassium currents I(Ks) and I(Kr) and the sodium current I(Na) give rise to several types of the long-QT syndrome. I(Ks) is heterogeneously distributed across the ventricular wall. METHODS AND RESULTS We investigated the effects of reducing I(Ks) or I(Kr) or enhancing late I(Na) (to simulate the 3 forms of long-QT syndrome) on action potential duration (APD) in the context of I(Ks) heterogeneity. We introduced I(Ks) heterogeneity in… CONTINUE READING

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