Cellular apoptosis susceptibility gene expression in endometrial carcinoma: correlation with Bcl-2, Bax, and caspase-3 expression and outcome.

@article{Peir2001CellularAS,
  title={Cellular apoptosis susceptibility gene expression in endometrial carcinoma: correlation with Bcl-2, Bax, and caspase-3 expression and outcome.},
  author={Gloria Peir{\'o} and Joachim Diebold and Gustavo Bruno Baretton and Rainer Kimmig and Udo Loehrs},
  journal={International journal of gynecological pathology : official journal of the International Society of Gynecological Pathologists},
  year={2001},
  volume={20 4},
  pages={359-67}
}
Deregulation of proliferation and apoptosis is known to contribute to neoplastic transformation and growth. Using specific antibodies for the cellular apoptosis susceptibility (CAS) gene, caspase-3, Bcl-2, and Bax, we examined the protein expression in 89 endometrial carcinomas and in 56 samples of nonneoplastic adjacent endometrium for comparison. Immunostaining results were scored with regard to approximate percentage of positive tumor cells (< 10%, 10% to 50%, > 50%) and relative… CONTINUE READING