Cellular antisense activity of peptide nucleic acid (PNAs) targeted to HIV-1 polypurine tract (PPT) containing RNA

@inproceedings{BoutimahHamoudi2007CellularAA,
  title={Cellular antisense activity of peptide nucleic acid (PNAs) targeted to HIV-1 polypurine tract (PPT) containing RNA},
  author={Fatima Boutimah-Hamoudi and Erwan Leforestier and Catherine S{\'e}namaud-Beaufort and Peter E. Nielsen and Carine Giovannangeli and Tula Ester Saison-Behmoaras},
  booktitle={Nucleic acids research},
  year={2007}
}
DNA and RNA oligomers that contain stretches of guanines can associate to form stable secondary structures including G-quadruplexes. Our study shows that the (UUAAAAGAAAAGGGGGGAU) RNA sequence, from the human immunodeficiency virus type 1 (HIV-1 polypurine tract or PPT sequence) forms in vitro a stable folded structure involving the G-run. We have investigated the ability of pyrimidine peptide nucleic acid (PNA) oligomers targeted to the PPT sequence to invade the folded RNA and exhibit… CONTINUE READING

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