Cellular and systemic effects of anthrax lethal toxin and edema toxin.

  title={Cellular and systemic effects of anthrax lethal toxin and edema toxin.},
  author={Mahtab Moayeri and Stephen H Leppla},
  journal={Molecular aspects of medicine},
  volume={30 6},
Anthrax lethal toxin (LT) and edema toxin (ET) are the major virulence factors of anthrax and can replicate the lethality and symptoms associated with the disease. This review provides an overview of our current understanding of anthrax toxin effects in animal models and the cytotoxicity (necrosis and apoptosis) induced by LT in different cells. A brief reexamination of early historic findings on toxin in vivo effects in the context of our current knowledge is also presented. 

From This Paper

Figures, tables, and topics from this paper.

Explore Further: Topics Discussed in This Paper


Publications citing this paper.
Showing 1-10 of 103 extracted citations


Publications referenced by this paper.
Showing 1-10 of 180 references

Pathophysiology of anthrax

S.H.M. Moayeri
Leppla / Molecular Aspects of Medicine • 2009
View 6 Excerpts
Highly Influenced

edema and hemorrhage

J. L. Larabee, K. Degiusti, J. L. Regens, J. D. Ballard
Microb. Pathog • 2008
View 7 Excerpts
Highly Influenced

Inflammatory caspases and inflammasomes: master switches of inflammation

Cell Death and Differentiation • 2007
View 8 Excerpts
Highly Influenced

macrophage cell death

S. D. Ha, D. Ng, S. L. Pelech, S. O. Kim
J. Biol. Chem • 2007
View 13 Excerpts
Highly Influenced

Anthrax lethal toxin induces endothelial barrier dysfunction.

The American journal of pathology • 2005
View 8 Excerpts
Highly Influenced

function together to worsen shock and outcome in a rat model

M. Moayeri, Y. Li, X. Li, M. Haley, Y Fitz
J. Infect. Dis • 2004
View 8 Excerpts
Highly Influenced

causes destabilization of interleukin-8 mRNA

F. A. Beall, F. G. Dalldorf
Cell Microbiol • 1966
View 4 Excerpts
Highly Influenced

Rat survival to anthrax lethal toxin is likely controlled by a single gene

The Pharmacogenomics Journal • 2008
View 5 Excerpts
Highly Influenced

Similar Papers

Loading similar papers…