Cellular and subcellular localization of tritiated gentamicin in the guinea pig cochlea following combined treatment with ethacrynic acid.

@article{Hiel1992CellularAS,
  title={Cellular and subcellular localization of tritiated gentamicin in the guinea pig cochlea following combined treatment with ethacrynic acid.},
  author={H Hiel and A Schamel and J P Erre and Tetsuro Hayashida and Didier Dulon and J-M. Aran},
  journal={Hearing research},
  year={1992},
  volume={57 2},
  pages={157-65}
}
Guinea pigs (GPs) receiving one intra-muscular injection of gentamicin (GM) (150 mg/kg) in which 2 mg of tritiated GM (2 mCi) were incorporated, followed 1.5 h later by an intra-cardiac injection of ethacrynic acid (EA) (30 mg/kg) were sacrificed 25 min, 1, 4 and 24 h after the EA injection. Other GPs were treated with one injection of GM or EA alone and sacrificed 24 h later. Cochlear function was monitored by recording VIIIth nerve compound action potential (CAP) responses to clicks at 70 dB… CONTINUE READING
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At 1 h a weak labelling was detected in vessels of the stria vascularis and in sensory cells at the base of the cochlea .
At 1 h a weak labelling was detected in vessels of the stria vascularis and in sensory cells at the base of the cochlea .
At 1 h a weak labelling was detected in vessels of the stria vascularis and in sensory cells at the base of the cochlea .
At 24 h GM labelling was found exclusively in hair cells , particularly outer hair cells , with a gradient from base to apex and from first to 3rd row , this distribution pattern correlating well with the pattern of threshold changes prominent at high frequencies.(ABSTRACT TRUNCATED AT 250 WORDS ) .
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