Cellular and subcellular localization of CXCL12 and CXCR4 in rat nociceptive structures: physiological relevance.

@article{Goazigo2012CellularAS,
  title={Cellular and subcellular localization of CXCL12 and CXCR4 in rat nociceptive structures: physiological relevance.},
  author={Annabelle Reaux-Le Goazigo and Cyril Rivat and Patrick Kitabgi and Michel Pohl and St{\'e}phane M{\'e}lik Parsadaniantz},
  journal={The European journal of neuroscience},
  year={2012},
  volume={36 5},
  pages={2619-31}
}
Initial studies implicated the chemokine CXC motif ligand 12 (CXCL12) and its cognate CXC motif receptor 4 (CXCR4) in pain modulation. However, there has been no description of the distribution, transport and axonal sorting of CXCL12 and CXCR4 in rat nociceptive structures, and their direct participation in nociception modulation has not been demonstrated. Here, we report that acute intrathecal administration of CXCL12 induced mechanical hypersensitivity in naive rats. This effect was prevented… CONTINUE READING