Cellular and subcellular heterogeneity of [Ca2+]i in single heart cells revealed by fura-2.

@article{Wier1987CellularAS,
  title={Cellular and subcellular heterogeneity of [Ca2+]i in single heart cells revealed by fura-2.},
  author={Withrow Gil Wier and Mark B. Cannell and Joshua R Berlin and Eduardo Marb{\'a}n and W. Jonathan Lederer},
  journal={Science},
  year={1987},
  volume={235 4786},
  pages={325-8}
}
Digital imaging of calcium indicator signals (fura-2 fluorescence) from single cardiac cells has revealed different subcellular patterns of cytoplasmic calcium ion concentration ([Ca2+]i) that are associated with different types of cellular appearance and behavior. In any population of enzymatically isolated rat heart cells, there are mechanically quiescent cells in which [Ca2+]i is spatially uniform, constant over time, and relatively low; spontaneously contracting cells, which have an… CONTINUE READING

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