Cellular and subcellular distribution of monocarboxylate transporters in cultured brain cells and in the adult brain.

@article{Pellerin2005CellularAS,
  title={Cellular and subcellular distribution of monocarboxylate transporters in cultured brain cells and in the adult brain.},
  author={Luc Pellerin and Linda H Bergersen and Andrew Philip Halestrap and Karin Pierre},
  journal={Journal of neuroscience research},
  year={2005},
  volume={79 1-2},
  pages={55-64}
}
Monocarboxylate transporters (MCTs) are involved in the uptake and release of lactate, pyruvate, and ketone bodies. Studies of their distribution at both the mRNA and protein levels have highlighted the specific expression of MCT1, MCT2, and more recently MCT4 in the central nervous system. MCT1 was found strongly expressed by cortical astrocytes both in vitro and in vivo. It was also found at high levels on blood vessels, ependymocytes, and glia limitans. A subset of neurons in vitro exhibited… CONTINUE READING
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