Cellular and subcellular alternans in the canine left ventricle.

  title={Cellular and subcellular alternans in the canine left ventricle.},
  author={Jonathan M. Cordeiro and Jane E Malone and Jos{\'e} M. Di Diego and Fabiana S. Scornik and Gary L. Aistrup and Charles Antzelevitch and John Andrew Wasserstrom},
  journal={American journal of physiology. Heart and circulatory physiology},
  volume={293 6},
Previous studies indicate that action potential duration (APD) alternans is initiated in the endocardial (END) and midmyocardial (MID) regions rather than the epicardium (EPI) in the canine left ventricle (LV). This study examines regional differences in the rate dependence of Ca(2+) transient characteristics under conditions that give rise to APD and associated T wave alternans. The role of the sarcoplasmic reticulum (SR) was further evaluated by studying Ca(2+) transient characteristics in… CONTINUE READING


Publications citing this paper.
Showing 1-10 of 28 extracted citations

Cellular mechanism of cardiac alternans: an unresolved chicken or egg problem

Journal of Zhejiang University SCIENCE B • 2014
View 3 Excerpts


Publications referenced by this paper.
Showing 1-10 of 39 references

Myocardial infarction in rat eliminates regional heterogeneity of AP profiles, Ito H3515 SUBCELLULAR ALTERNANS IN VENTRICULAR MYOCYTES AJP-Heart Circ Physiol

R Kaprielian, R Sah, T Nguyen, AD Wickenden, PH. Backx
Am J Physiol Heart Circ Physiol 283: H1157–H1168, • 2007
View 1 Excerpt

Identification of cellular and subcellular alternans by confocal microscopy in the canine left ventricle (Abstract)

JE Malone, JM Cordeiro, +4 authors JA. Wasserstrom
Biophys J • 2006
View 1 Excerpt

Similar Papers

Loading similar papers…