Cellular and nuclear degradation during apoptosis.

  title={Cellular and nuclear degradation during apoptosis.},
  author={Bin He and Nan Lu and Zheng Zhou},
  journal={Current opinion in cell biology},
  volume={21 6},
Apoptosis ensures quick death and quiet clearance of unwanted or damaged cells, without inducing much, if any, immunological responses from the organism. In metazoan organisms, apoptotic cells are swiftly engulfed by other cells. The degradation of cellular content is initiated in apoptotic cells and completed within engulfing cells. In apoptotic cells, caspase-mediated proteolysis cleaves protein substrates into fragments; nuclear DNA is partially degraded into nucleosomal units; and autophagy… CONTINUE READING