Cellular and molecular requirements for rejection of B16 melanoma in the setting of regulatory T cell depletion and homeostatic proliferation.

@article{Kline2012CellularAM,
  title={Cellular and molecular requirements for rejection of B16 melanoma in the setting of regulatory T cell depletion and homeostatic proliferation.},
  author={Justin P. Kline and Long Zhang and Lauren Battaglia and Kenneth S. Cohen and Thomas F Gajewski},
  journal={Journal of immunology},
  year={2012},
  volume={188 6},
  pages={
          2630-42
        }
}
We have recently demonstrated that adoptive transfer of regulatory T cell-depleted polyclonal T cells into lymphopenic mice leads to rejection of B16 melanoma, which generated an opportunity to study host requirements for tumor rejection when it effectively occurred. CD8(+) T cell priming and tumor rejection required tumor Ag cross-presentation, as evidenced by tumor outgrowth in Kb(-/-) bone marrow chimeric or B71/2(-/-) mice. CD4(+) T cells were additionally required for optimal tumor control… CONTINUE READING
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