Cellular and molecular regulation of muscle regeneration.

  title={Cellular and molecular regulation of muscle regeneration.},
  author={Sophie B. P. Charg{\'e} and M. Rudnicki},
  journal={Physiological reviews},
  volume={84 1},
  • Sophie B. P. Chargé, M. Rudnicki
  • Published 2004
  • Biology, Medicine
  • Physiological reviews
  • Under normal circumstances, mammalian adult skeletal muscle is a stable tissue with very little turnover of nuclei. However, upon injury, skeletal muscle has the remarkable ability to initiate a rapid and extensive repair process preventing the loss of muscle mass. Skeletal muscle repair is a highly synchronized process involving the activation of various cellular responses. The initial phase of muscle repair is characterized by necrosis of the damaged tissue and activation of an inflammatory… CONTINUE READING
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