Cellular and molecular pathology of medulloblastoma

  title={Cellular and molecular pathology of medulloblastoma},
  author={John Peter Provias and Laurence Edward Becker},
  journal={Journal of Neuro-Oncology},
Medulloblastoma is a malignant embryonal tumor predominantly of childhood. It occurs principally in the midline cerebellar region but is prone to invade the meninges and cerebrospinal fluid spaces. It is the principal posterior fossa tumor in children and represents 20% of all brain tumors in this age group. Considerable advances have been made in characterizing the morphologic subtypes, immunophenotypes, and in vitro behavior of cell lines. However, the cell of origin and its relationship to… CONTINUE READING


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