Cellular and molecular pathogenesis of systemic lupus erythematosus: lessons from animal models

@inproceedings{Pathak2011CellularAM,
  title={Cellular and molecular pathogenesis of systemic lupus erythematosus: lessons from animal models},
  author={Shilpa Pathak and Chandra Mohan},
  booktitle={Arthritis research & therapy},
  year={2011}
}
Systemic lupus erythematosus (SLE) is a complex disease characterized by the appearance of autoantibodies against nuclear antigens and the involvement of multiple organ systems, including the kidneys. The precise immunological events that trigger the onset of clinical manifestations of SLE are not yet well understood. However, research using various mouse strains of spontaneous and inducible lupus in the last two decades has provided insights into the role of the immune system in the… CONTINUE READING

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