Cellular and molecular mechanisms underlying age-related skeletal muscle wasting and weakness

@article{Ryall2008CellularAM,
  title={Cellular and molecular mechanisms underlying age-related skeletal muscle wasting and weakness},
  author={James G. Ryall and Jonathan D. Schertzer and Gordon S. Lynch},
  journal={Biogerontology},
  year={2008},
  volume={9},
  pages={213-228}
}
Some of the most serious consequences of ageing are its effects on skeletal muscle. The term ‘sarcopenia’ describes the slow but progressive loss of muscle mass with advancing age and is characterised by a deterioration of muscle quantity and quality leading to a gradual slowing of movement and a decline in strength. The loss of muscle mass and strength is thought to be attributed to the progressive atrophy and loss of individual muscle fibres associated with the loss of motor units, and a… 

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