Cellular and molecular mechanisms of presynaptic assembly

@article{Ziv2004CellularAM,
  title={Cellular and molecular mechanisms of presynaptic assembly},
  author={N. Ziv and C. Garner},
  journal={Nature Reviews Neuroscience},
  year={2004},
  volume={5},
  pages={385-399}
}
  • N. Ziv, C. Garner
  • Published 2004
  • Biology, Medicine
  • Nature Reviews Neuroscience
The formation of a presynaptic neurotransmitter secretion site involves the transformation of a patch of unspecialized plasma membrane into a complex structure that is highly specialized for sustained, depolarization-evoked synaptic vesicle exocytosis. This transformation is governed by dynamic intracellular and intercellular processes, and by global developmental processes. Recent work has shed light on the cellular processes that are responsible for transporting presynaptic molecules to… Expand

Figures, Tables, and Topics from this paper

Presynaptic Development and Active Zones
TLDR
Key cellular and molecular mechanisms involved in presynaptic development, which involves the transformation of a patch of unspecialized plasma membrane into a complex structure that is highly specialized for sustained, depolarization-evoked synaptic vesicle exocytosis, are reviewed. Expand
Molecular organization of the presynaptic active zone
TLDR
Five protein families whose members are highly enriched at active zones (Munc13s, RIMs, ELKS proteins, Piccolo and Bassoon, and the liprins-α), have been characterized and are instrumental for the diverse functions performed by the presynaptic active zone. Expand
Endocytosis and Presynaptic Scaffolds
TLDR
Current knowledge about the pathways of SV cycling, the role that membrane lipids may play in coordinating the different steps of the vesicle cycle, and the protein scaffolds that spatially coordinate molecular interactions and perhaps vesicles movement are reviewed. Expand
Molecular mechanisms of presynaptic differentiation.
TLDR
This review highlights the recent findings pertaining to the cellular and molecular regulation of presynaptic differentiation and describes the mechanisms behind the specificity and dynamics of synapses. Expand
Presynaptic Development: Functional and Morphological Organization
TLDR
Functional studies have been instrumental in defining distinct stages of presynaptic assembly and maturation during development and the identification of specific synaptic cell adhesion molecules that initiate synapse assembly and bridge the synaptic cleft in mature synapses. Expand
Synaptogenic pathways
TLDR
This work presents a summary of the current understanding of synaptogenic pathways that mediate presynaptic and postsynaptic assembly and the coordination of these processes. Expand
Mechanisms That Regulate Neuronal Protein Clustering at the Synapse
There is considerable evidence that synaptic contact formation and remodeling is regulated by assembly of several important classes of proteins, including neurotransmitter receptors, adhesionExpand
Molecular organization and assembly of the presynaptic active zone of neurotransmitter release.
TLDR
This review is focused on a set of specific proteins involved in the structural and functional organization of the CAZ, which postulates that active zones, at least in part, are pre-assembled in neuronal cell bodies and transported as so-called Piccolo-Bassoon transport vesicles (PTVs) to sites of synaptogenesis. Expand
Molecular Composition of Developing Glutamatergic Synapses
TLDR
In this chapter, current knowledge of the mechanisms that govern the trafficking and recruitment of synaptic proteins to newly forming glutamatergic synapses is discussed. Expand
Liprin-alpha Proteins Regulate Neuronal Development and Synapse Function
TLDR
The diversity of liprin binding partners, the factors that control the function of Liprin-I±s at the synapse, and how liprin- I± family proteins regulate synapse formation and synaptic transmission are investigated. Expand
...
1
2
3
4
5
...

References

SHOWING 1-10 OF 231 REFERENCES
Cell biology of the presynaptic terminal.
TLDR
The current understanding of how synaptic morphology is maintained is reviewed and then the mechanisms in synaptic vesicle exocytosis and recycling are reviewed. Expand
Synaptic vesicle phosphoproteins and regulation of synaptic function.
TLDR
Current understanding of the mechanism by which synapsin I modulates communication between nerve cells is described and the properties and putative functions of other phosphoproteins associated with synaptic vesicles are reviewed. Expand
Assembly of presynaptic active zones from cytoplasmic transport packets
TLDR
Time-lapse fluorescence imaging, immunocytochemistry and electron microscopy are used to study hippocampal neuronal cultures transfected with a fusion construct of the presynaptic vesicle protein VAMP and green fluorescent protein to suggest that substantial membrane remodeling may be necessary to produce the uniform vesicles typical of the mature active zone. Expand
The presynaptic cytomatrix of brain synapses
TLDR
This review will review the present view of how the exocytotic and endocytic machineries at the site of neurotransmitter release are linked to and organized by the presynaptic cytoskeleton and summarize recent progress that has been made in understanding how active zones are assembled during nervous system development. Expand
Endocytotic mechanisms in synapses.
TLDR
The remarkable speed and selectivity of compensatory endocytosis may be achieved by concentrating the machinery at specialized sites in the nerve terminal adjacent to exocytotic sites and by the use of neuronal isoforms of the proteins that mediate endocyTosis. Expand
Distribution of neurotransmitter secretion in growing axons
TLDR
The existence of a previously undetected early stage of axonal growth is revealed and developmental regulation in the pattern of neurotransmitter secretion along the growing nerve processes is suggested. Expand
Assembling the Presynaptic Active Zone A Characterization of an Active Zone Precursor Vesicle
TLDR
The results show that Piccolo is transported to nascent synapses on an approximately 80 nm dense core granulated vesicle together with other constituents of the active zone, including Bassoon, Syntaxin, SNAP-25, and N-cadherin, as well as chromogranin B. Expand
Temporal and spatial coordination of exocytosis and endocytosis
TLDR
Emerging insights into the coupling of exocytic and endocytic processes are discussed, both in the chemical synapses of neurons and in non-neuronal cells. Expand
Calcium Dependence of Synaptic Vesicle Recycling Before and After Synaptogenesis
TLDR
Data suggest that formation of synapses correlates with the activation of a putative low‐affinity calcium sensor, which allows synaptic vesicle exocytosis to be triggered and turned off over extremely short time scales, in response to large increases in the level of intracellular calcium. Expand
α-Neurexins couple Ca2+ channels to synaptic vesicle exocytosis
TLDR
Using triple-knockout mice, it is shown that α-neurexins are not required for synapse formation, but are essential for Ca2+-triggered neurotransmitter release. Expand
...
1
2
3
4
5
...