Cellular and molecular mechanisms of murine autoimmune myocarditis.

  title={Cellular and molecular mechanisms of murine autoimmune myocarditis.},
  author={Josef M. Penninger and C L Pummerer and Peter J Y Liu and Nikolaus Neu and Kurt W Bachmaier},
  journal={APMIS : acta pathologica, microbiologica, et immunologica Scandinavica},
  volume={105 1},
Dilated cardiomyopathy is a prevalent cause of progressive heart disease and sudden death, and most patients with cardiomyopathy have a history of viral myocarditis. Coxsackie B3 (CB3) picornaviruses can be detected in as many as 50% of these patients and CB3 infections have been epidemiologically linked to chronic heart disease. Several clinical and experimental studies suggest that chronic stages of disease are mediated by an autoimmune response against heart muscle myosin. Human heart… CONTINUE READING